HitPredict

Interactor 1: TAGL2 (P37802)
Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)
Gene: TAGLN2

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 21577206
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0031982 - vesicle GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 199 Hs			1 375
+	Hs
		741855 TAGL2_HUMAN (1-199): 1.65e-87: 257: 100.00		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		741856 TAGL2_HUMAN (1-199): 1.65e-87: 257: 100.00		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		891782 CNN3_HUMAN (3-198): 1.27e-77: 237: 43.37		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891988 CNN2_HUMAN (3-198): 1.69e-74: 228: 40.31		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932175 CNN3_HUMAN (3-198): 1.27e-77: 237: 43.37		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Rn
		933100 CNN1_RAT (3-198): 7.04e-75: 229: 42.35		ACTS_RAT (2-375): 0: 592: 93.58
+	Hs
		932344 CNN2_HUMAN (3-198): 1.69e-74: 228: 40.31		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		851163 CNN1_HUMAN (3-198): 7.89e-74: 226: 42.86		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Dm
		862565 Q9I7J0_DROME (22-198): 5.75e-61: 189: 35.03		ACT3_DROME (2-375): 0: 594: 95.46
+	Hs
		809232 IQGA1_HUMAN (4-181): 5.8e-46: 163: 17.99		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		809257 IQGA1_HUMAN (4-181): 5.8e-46: 163: 17.99		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		891748 IQGA2_HUMAN (4-181): 4.11e-45: 161: 16.93		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Sc
		887705 SCP1_YEAST (4-199): 1.16e-52: 169: 32.18		ACT_YEAST (1-375): 0: 591: 88.80
+	Sp
		144980 IQG1_SCHPO (4-158): 4.21e-38: 141: 18.71		ACT_SCHPO (1-375): 0: 592: 90.40
+	Sc
		887718 IQG1_YEAST (7-169): 1.15e-32: 125: 20.00		ACT_YEAST (1-375): 0: 591: 88.80
+	Hs
		933037 LRCH3_HUMAN (2-143): 2.63e-31: 121: 19.31		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		892114 LIMC1_HUMAN (29-138): 3.62e-13: 69.3: 24.59		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891926 LMO7_HUMAN (34-153): 4.13e-13: 68.9: 24.24		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932285 LMO7_HUMAN (34-153): 4.13e-13: 68.9: 24.24		ACTC_HUMAN (2-375): 0: 592: 94.12