HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10852916
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 576
+	Hs
		794388 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		GRK6_HUMAN (1-576): 0: 573: 100.00
+	Hs
		714489 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		282772 SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00		GRK6_HUMAN (1-576): 0: 573: 100.00
+	Hs
		714539 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		742316 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		GRK1_HUMAN (3-537): 1.99e-153: 453: 47.96
+	Hs
		742230 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09
+	Hs
		626629 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59
+	Rn
		448412 SYUA_RAT (1-140): 2.23e-57: 176: 95.00		KPCE_RAT (11-507): 1.72e-145: 439: 24.28
+	Hs
		282769 SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		742241 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86
+	Hs
		681700 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59
+	Hs
		1079321 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		GRK1_HUMAN (3-537): 1.99e-153: 453: 47.96
+	Hs
		282779 SYUG_HUMAN (1-100): 1.25e-28: 103: 66.00		GRK1_HUMAN (3-537): 1.99e-153: 453: 47.96
+	Hs
		681868 SYUB_HUMAN (1-126): 2.84e-36: 122: 58.02		AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59
+	Hs
		566312 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08