HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

Property	Details
Experiments	24895406, 32814053
Identification Methods	fluorescence polarization spectroscopy, two hybrid array, two hybrid pooling approach, validated two hybrid, circular dichroism
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 246
+	Mm
		223032 SYUA_MOUSE (1-140): 4.44e-57: 175: 95.00		1433F_MOUSE (1-246): 6.15e-136: 383: 99.19
+	Hs
		742202 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Rn
		716561 SYUA_RAT (1-140): 2.23e-57: 176: 95.00		1433B_RAT (3-245): 9.89e-106: 307: 74.69
+	Hs
		646692 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43