HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	36634849, 30021006, 37010382, 24831002
Identification Methods	proximity labelling technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 975
+	Hs
		742119 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125201 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		742545 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		742540 SYUA_HUMAN (1-140): 5.01e-57: 175: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56