HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: PARK7 (Q99497)
Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124)
Gene: PARK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

The method score is based on:

Property	Details
Experiments	25058424, 15935068, 15502874
Identification Methods	protein complementation assay, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005507 - copper ion binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol and 10 others more... GO:0005886 - plasma membrane GO:0006469 - negative regulation of protein kinase activity GO:0008344 - adult locomotory behavior GO:0030424 - axon GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0034599 - cellular response to oxidative stress GO:0043524 - negative regulation of neuron apoptotic process GO:0048471 - perinuclear region of cytoplasm GO:0051583 - dopamine uptake involved in synaptic transmission GO:1903136 - cuprous ion binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	140
Hs

1	189

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024