HitPredict

Interactor 1: KPR4 (P38063)
Ribose-phosphate pyrophosphokinase 4 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 4)
Gene: PRS4

Interactor 2: KPR5 (Q12265)
Ribose-phosphate pyrophosphokinase 5 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 5)
Gene: PRS5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.938

The method score is based on:

Property Details
Experiments 17892321, 11283351, 10212224, 30649305, 27744273, 37968396
Identification Methods anti tag coimmunoprecipitation, two hybrid pooling approach, two hybrid, affinity chromatography technology
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
and 6 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 326
Sc

1 496
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+ Ce
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+ Dm
+ Hs
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+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024