HitPredict

Interactor 1: AP2A (P38065)
AP-2 complex subunit alpha (Alpha-adaptin) (Clathrin assembly protein complex 2 alpha large chain) (Clathrin assembly protein large alpha chain)
Gene: APL3

Interactor 2: AP2S (Q00381)
AP-2 complex subunit sigma (Adaptin small chain) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)
Gene: APS2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	11805826, 18719252, 37968396, 16429126
Identification Methods	tandem affinity purification, two hybrid, affinity chromatography technology
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005935 - cellular bud neck GO:0006886 - intracellular protein transport GO:0030122 - AP-2 adaptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1025 Sc			1 147
+	Mm
		567520 AP2A2_MOUSE (11-1023): 0: 680: 22.32		AP2S1_MOUSE (3-147): 5.37e-43: 140: 48.97
+	Hs
		321516 AP2A1_HUMAN (11-1023): 0: 676: 21.52		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Hs
		302125 AP2A2_HUMAN (11-1023): 0: 673: 22.10		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Dm
		954832 AP2A_DROME (12-1023): 0: 653: 23.00		Q9VDC3_DROME (3-147): 3.36e-43: 141: 48.28
+	Ce
		1090495 Q22601_CAEEL (13-1023): 0: 634: 21.69		Q19123_CAEEL (3-147): 6.32e-44: 142: 48.28
+	At
		1196568 AP2A1_ARATH (17-1023): 0: 600: 21.74		AP2S_ARATH (3-147): 1.28e-40: 134: 48.97
+	Hs
		212676 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		212662 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Mm
		612130 AP1G1_MOUSE (21-876): 0: 570: 18.76		AP1M1_MOUSE (1-142): 5.37e-45: 153: 14.79
+	Hs
		212611 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		212614 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		212659 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		926066 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP1M2_HUMAN (1-147): 6.51e-46: 155: 16.89
+	Hs
		925992 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP1M1_HUMAN (1-142): 6.09e-45: 153: 14.79
+	Hs
		212608 AP1G1_HUMAN (21-876): 0: 570: 18.76		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Hs
		880408 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP1S2_HUMAN (3-147): 1.37e-46: 150: 40.00
+	Hs
		903681 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP1S1_HUMAN (3-147): 4.12e-46: 148: 37.93
+	Hs
		925978 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP1S3_HUMAN (3-147): 7.59e-44: 143: 42.76
+	Hs
		864065 AP2B1_HUMAN (43-1018): 0: 558: 12.57		AP2S1_HUMAN (3-147): 5.37e-43: 140: 48.97
+	Hs
		902381 COPG2_HUMAN (29-1015): 0: 556: 10.85		COPZ1_HUMAN (2-143): 4.48e-40: 134: 16.08