HitPredict

Interactor 1: LSM2 (P38203)
U6 snRNA-associated Sm-like protein LSm2 (Small nuclear ribonucleoprotein D homolog SNP3)
Gene: LSM2

Interactor 2: PRP3 (Q03338)
U4/U6 small nuclear ribonucleoprotein PRP3 (Pre-mRNA-splicing factor 3)
Gene: PRP3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DUF1115~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071001 - U4/U6 snRNP
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 95 Sc			1 469
+	Sc
		795412 SMD3_YEAST (2-88): 5.25e-29: 101: 17.24		PRP3_YEAST (1-469): 0: 580: 100.00
+	Sc
		767823 LSM4_YEAST (1-83): 6.06e-25: 93.9: 27.17		PRP3_YEAST (1-469): 0: 580: 100.00
+	Hs
		202552 LSM2_HUMAN (1-95): 4.64e-40: 129: 63.16		PRPF3_HUMAN (43-464): 2.63e-115: 355: 24.03
+	Hs
		202556 LSM4_HUMAN (1-95): 1.42e-35: 119: 29.90		PRPF3_HUMAN (43-464): 2.63e-115: 355: 24.03
+	Hs
		202410 SMD3_HUMAN (2-88): 1.96e-32: 111: 17.24		PRPF3_HUMAN (43-464): 2.63e-115: 355: 24.03
+	Hs
		202408 SMD1_HUMAN (1-95): 1.45e-26: 95.8: 27.37		PRPF3_HUMAN (43-464): 2.63e-115: 355: 24.03
+	Hs
		202404 RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29		PRPF3_HUMAN (43-464): 2.63e-115: 355: 24.03