HitPredict

Interactor 1: SLT11 (P38241)
Pre-mRNA-splicing factor SLT11 (Extracellular mutant protein 2) (Synthetic lethality with U2 protein 11)
Gene: ECM2

Interactor 2: CEF1 (Q03654)
Pre-mRNA-splicing factor CEF1 (PRP nineteen-associated complex protein 85) (PRP19-associated complex protein 85)
Gene: CEF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	11805826, 37968396, 11884590, 16429126, 29146870, 30879786
Identification Methods	tandem affinity purification, affinity chromatography technology, pull down, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0071006 - U2-type catalytic step 1 spliceosome
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 364 Sc			1 590
+	Sp
		223707 SLT11_SCHPO (10-255): 6e-106: 316: 29.96		CEF1_SCHPO (8-531): 2.5e-85: 283: 27.98
+	Hs
		1303800 RBM22_HUMAN (10-271): 2.18e-64: 212: 23.13		CDC5L_HUMAN (1-537): 2.19e-100: 324: 29.51
+	At
		955174 C3H4_ARATH (10-271): 2.17e-65: 216: 24.31		CDC5L_ARATH (4-461): 1.98e-82: 277: 30.84
+	At
		186560 C3H25_ARATH (10-271): 1.16e-65: 217: 23.96		O22179_ARATH (10-126): 1.38e-42: 156: 27.12