HitPredict

Interactor 1: SLT11 (P38241)
Pre-mRNA-splicing factor SLT11 (Extracellular mutant protein 2) (Synthetic lethality with U2 protein 11)
Gene: ECM2

Interactor 2: CLF1 (Q12309)
Pre-mRNA-splicing factor CLF1 (Crooked neck-like factor 1) (PRP19-associated complex protein 77) (Synthetic lethal with CDC40 protein 3)
Gene: CLF1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	11805826, 12509417, 16429126, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0071006 - U2-type catalytic step 1 spliceosome GO:0071007 - U2-type catalytic step 2 spliceosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 364 Sc			1 687
+	Sc
		746876 SLT11_YEAST (1-364): 0: 581: 100.00		SYF1_YEAST (54-674): 1.42e-57: 211: 11.97
+	Dm
		54165 Q95RB1_DROME (10-271): 2.04e-57: 194: 22.45		SYF1_DROME (3-674): 1.7e-77: 267: 14.23
+	Hs
		175249 RBM22_HUMAN (10-271): 2.18e-64: 212: 23.13		OGT1_HUMAN (3-340): 4.64e-40: 160: 14.12
+	Hs
		1199249 RBM22_HUMAN (10-271): 2.18e-64: 212: 23.13		PRP39_HUMAN (187-617): 5.38e-18: 90.3: 13.82
+	Hs
		300273 RBM22_HUMAN (10-271): 2.18e-64: 212: 23.13		PRP6_HUMAN (449-672): 5e-10: 64.9: 11.89