HitPredict

Interactor 1: EIF3A (P38249)
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 110 kDa subunit homolog) (eIF3 p110) (Translation initiation factor eIF3, p110 subunit homolog)
Gene: RPG1

Interactor 2: IF5 (P38431)
Eukaryotic translation initiation factor 5 (eIF-5)
Gene: TIF5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	11179233, 15838098, 16429126, 11018020, 16554755, 37968396, 21280672
Identification Methods	coimmunoprecipitation, affinity chromatography technology, biochemical, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001732 - formation of cytoplasmic translation initiation complex GO:0003743 - translation initiation factor activity GO:0033290 - eukaryotic 48S preinitiation complex GO:0043614 - multi-eIF complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 964 Sc			1 405
+	Hs
		873838 EIF3A_HUMAN (1-963): 7.52e-106: 361: 22.66		IF5_HUMAN (1-395): 1.09e-129: 381: 36.66
+	Sc
		447181 EIF3A_YEAST (1-964): 3.87e-117: 383: 100.00		IF2B_YEAST (3-130): 9.03e-44: 155: 25.93
+	Hs
		1049693 EIF3A_HUMAN (1-963): 7.52e-106: 361: 22.66		5MP1_HUMAN (214-395): 2.15e-31: 125: 15.98
+	Hs
		148387 CTRO_HUMAN (436-962): 2.82e-21: 102: 9.63		IF2B_HUMAN (3-130): 4.76e-42: 152: 24.06
+	Hs
		1025713 MYO5A_HUMAN (363-940): 1.38e-27: 123: 11.61		EI2BE_HUMAN (204-393): 1.87e-09: 61.4: 16.06
+	Hs
		1025695 MYO5C_HUMAN (580-961): 4.84e-09: 62.6: 8.77		EI2BE_HUMAN (204-393): 1.87e-09: 61.4: 16.06