HitPredict

Interactor 1: MED8 (P38304)
Mediator of RNA polymerase II transcription subunit 8 (Mediator complex subunit 8)
Gene: MED8

Interactor 2: MED31 (P38633)
Mediator of RNA polymerase II transcription subunit 31 (Hpr1 suppressor protein 1) (Mediator complex subunit 31)
Gene: SOH1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

The method score is based on:

Property	Details
Experiments	11283351, 15356001, 16554755, 16962561, 37968396, 16429126
Identification Methods	two hybrid pooling approach, affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med31~Med8
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II and 3 others more... GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	223
Sc

1	127

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024