HitPredict

Interactor 1: ARPC1 (P38328)
Actin-related protein 2/3 complex subunit 1 (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARC40

Interactor 2: MYO5 (Q04439)
Myosin-5 (Actin-dependent myosin-I MYO5) (Class I unconventional myosin MYO5) (Type I myosin MYO5)
Gene: MYO5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.715

Property	Details
Experiments	10648568, 25268174, 15485833, 18467557, 37968396
Identification Methods	two hybrid, pull down, protein complementation assay, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015629 - actin cytoskeleton GO:0030479 - actin cortical patch GO:0051015 - actin filament binding GO:2000601 - positive regulation of Arp2/3 complex-mediated actin nucleation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 384 Sc			1 1219
+	Sc
		730552 ARPC1_YEAST (1-384): 7.16e-76: 241: 96.62		MYO3_YEAST (1-1205): 0: 1087: 72.08
+	Sp
		945010 ARPC1_SCHPO (10-384): 2.49e-84: 263: 40.21		MYO1_SCHPO (1-1219): 0: 1043: 51.57
+	Hs
		1021692 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYO1E_HUMAN (24-1145): 0: 1052: 36.98
+	Hs
		724952 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Sc
		863635 COPA_YEAST (2-371): 4.32e-26: 112: 8.66		MYO5_YEAST (1-1219): 0: 1126: 100.00
+	Hs
		725215 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYH10_HUMAN (2-1099): 0: 1013: 24.07
+	Hs
		903182 WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75		MYO1E_HUMAN (24-1145): 0: 1052: 36.98
+	Hs
		728492 POC1A_HUMAN (144-384): 3.45e-45: 162: 11.93		MYH11_HUMAN (5-1118): 0: 1018: 24.03
+	Hs
		168741 ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96		MYH9_HUMAN (7-1119): 0: 1017: 23.96
+	Hs
		168742 ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96		MYH10_HUMAN (2-1099): 0: 1013: 24.07
+	Hs
		117789 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		214638 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYO1B_HUMAN (36-730): 5.19e-171: 538: 39.72
+	Hs
		117649 WDR5_HUMAN (182-383): 7.51e-36: 135: 12.75		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		117536 CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		117516 ARC1B_HUMAN (21-245): 1.19e-12: 70.5: 8.96		MYO1C_HUMAN (31-736): 0: 570: 41.82
+	Hs
		214444 CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56		MYO1B_HUMAN (36-730): 5.19e-171: 538: 39.72
+	Hs
		282792 CIAO1_HUMAN (7-142): 6.72e-21: 94.4: 14.56		MYO1D_HUMAN (35-766): 3.11e-167: 524: 39.69
+	Hs
		1281512 FBXW7_HUMAN (1-321): 3.45e-66: 224: 11.89		MYO5A_HUMAN (712-1118): 1.31e-10: 68.2: 9.31