Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 25184681, 14578343, 11573086, 9525870, 26778126, 27977889, 27312108, 29180510, 29656893, 29899443, 25091198, 32092106, 29367421, 16543155, 34591612, 16818604, 20351172, 21965653, 11927591, 21880590 and 5 others

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Identification Methods affinity chromatography technology, unspecified method, x-ray crystallography, pull down, enzymatic study, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000724 - double-strand break repair via homologous recombination
GO:0000800 - lateral element
GO:0000931 - gamma-tubulin ring complex
and 71 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 1863
+ Mm
+ Hs
+ Hs
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+ Hs
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+ At
+ Hs
+ Hs
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+ Xl

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Last updated: 15 Jul 2024