HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 0.60 0.689

The method score is based on:

Property Details
Experiments 26831064, 15034933, 10943845, 23438604
Identification Methods affinity chromatography technology, biochemical, pull down
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002039 - p53 binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
and 7 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 1647
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024