HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: MAT1 (P51948)
CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)
Gene: MNAT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	15282296, 22493164
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 309
+	Hs
		584908 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851289 TRI39_HUMAN (15-389): 8.42e-67: 238: 13.19		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851282 TRIM5_HUMAN (10-339): 1.37e-63: 227: 13.27		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851296 TRI17_HUMAN (10-327): 9.61e-62: 221: 11.85		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851242 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851279 TRI34_HUMAN (11-303): 9.73e-48: 181: 14.62		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00
+	Hs
		851280 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MAT1_HUMAN (1-309): 6.09e-158: 444: 100.00