HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	25184681, 26831064, 8955125, 9497340
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 529
+	Hs
		131390 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		749261 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		134947 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		536764 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		853457 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		131500 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06