HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	25184681, 11498787, 10783165
Identification Methods	affinity chromatography technology, two hybrid, pull down, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage and 1 others more... GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1360
+	Hs
		594170 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		749193 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Hs
		855519 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		331732 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		855538 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		594210 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		794304 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Ce
		80828 BRCA1_CAEEL (10-378): 2.18e-39: 159: 15.88		MSH5_CAEEL (576-1355): 9.25e-142: 469: 17.00