HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: HNRH2 (P55795)
Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]
Gene: HNRNPH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26831064
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 449
+	Hs
		749450 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PABP4_HUMAN (1-447): 1.01e-81: 266: 13.59
+	Hs
		516390 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PABP1_HUMAN (1-448): 4.82e-81: 264: 12.29
+	Hs
		682711 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		HNRH1_HUMAN (1-449): 2.8e-73: 239: 96.21
+	Hs
		749264 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		HNRPF_HUMAN (1-434): 2.49e-60: 204: 71.72
+	Hs
		749512 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SART3_HUMAN (2-217): 3.71e-16: 83.3: 23.45
+	Hs
		682556 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		HNRH3_HUMAN (10-86): 8.49e-10: 62.2: 33.77
+	Hs
		582105 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		NUCL_HUMAN (4-404): 6.61e-09: 60.2: 18.16
+	Hs
		1031425 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		PABP4_HUMAN (1-447): 1.01e-81: 266: 13.59
+	Hs
		1119142 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		PAP1L_HUMAN (1-446): 4e-77: 253: 12.42
+	Hs
		536739 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		HNRH1_HUMAN (1-449): 2.8e-73: 239: 96.21
+	Hs
		682972 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		HNRH1_HUMAN (1-449): 2.8e-73: 239: 96.21
+	Hs
		1031451 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		PABP4_HUMAN (1-447): 1.01e-81: 266: 13.59
+	Hs
		516681 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		PABP1_HUMAN (1-448): 4.82e-81: 264: 12.29
+	Hs
		878730 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		HNRH2_HUMAN (1-449): 1.46e-74: 242: 100.00
+	Hs
		682970 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		HNRH1_HUMAN (1-449): 2.8e-73: 239: 96.21
+	Hs
		855204 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		HNRPF_HUMAN (1-434): 2.49e-60: 204: 71.72
+	Hs
		682671 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		HNRH3_HUMAN (10-86): 8.49e-10: 62.2: 33.77
+	Hs
		582480 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		NUCL_HUMAN (4-404): 6.61e-09: 60.2: 18.16