HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	17511879
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 327
+	Hs
		749316 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737621 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		749356 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PP2AA_HUMAN (8-303): 2.77e-176: 491: 45.79
+	Hs
		737950 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		536746 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		738001 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		738025 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		PP1G_HUMAN (1-327): 0: 569: 86.89