HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.613

The method score is based on:

Property Details
Experiments 25223785, 10608806
Identification Methods affinity chromatography technology, pull down, unspecified method
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006302 - double-strand break repair
GO:0006974 - DNA damage response
and 4 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 4128
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Xl
+ Hs
+ Xl
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024