HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36089195
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 136
+	Hs
		749363 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		935052 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952508 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		584928 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		477686 TRI49_HUMAN (10-334): 1.76e-61: 220: 12.84		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		1157225 TRIM4_HUMAN (15-377): 1.5e-62: 225: 11.52		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		935164 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952582 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		952608 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		H33_HUMAN (1-136): 1.12e-59: 182: 100.00