HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: CREB5 (Q02930)
Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa)
Gene: CREB5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25184681
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 508
+	Hs
		568071 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		JUND_HUMAN (173-450): 4.53e-29: 119: 14.95
+	Hs
		401546 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31
+	Hs
		566731 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		JUNB_HUMAN (191-447): 3.94e-24: 105: 15.14
+	Mm
		562974 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		ATF2_MOUSE (10-503): 1.25e-56: 198: 33.73
+	Mm
		404126 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		JUN_MOUSE (180-452): 1.89e-29: 120: 17.90
+	Hs
		536790 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		CREB5_HUMAN (1-508): 3.92e-104: 322: 100.00
+	Hs
		402389 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		JUN_HUMAN (180-452): 7.82e-29: 118: 18.31