HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: CSTF1 (Q05048)
Cleavage stimulation factor subunit 1 (CF-1 50 kDa subunit) (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50)
Gene: CSTF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	29180510, 11257228, 34591612
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 431
+	Hs
		749312 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		749840 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBL1R_HUMAN (4-293): 1.29e-53: 188: 12.68
+	Hs
		749764 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SNR40_HUMAN (3-195): 1.23e-28: 117: 19.50
+	Hs
		749954 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		PRP19_HUMAN (136-335): 3.89e-14: 76.3: 24.50
+	Hs
		1266889 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		NLE1_HUMAN (247-429): 1.25e-46: 169: 18.48
+	Hs
		983009 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		CSTF1_HUMAN (1-431): 3.08e-106: 322: 100.00
+	Hs
		585027 RO52_HUMAN (15-390): 2.55e-68: 241: 12.86		FBXW7_HUMAN (2-196): 3e-19: 92.1: 12.75
+	Hs
		903462 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		WDR5_HUMAN (2-289): 2.37e-58: 196: 17.75
+	Hs
		1019346 TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53		FBXW7_HUMAN (2-196): 3e-19: 92.1: 12.75
+	Hs
		1318524 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		PRP19_HUMAN (136-335): 3.89e-14: 76.3: 24.50