HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	26831064, 10220405
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 425
+	Hs
		749539 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		749840 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		TBL1R_HUMAN (109-424): 2.86e-60: 205: 16.52
+	Hs
		749312 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		1266889 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58
+	Hs
		1083377 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		1290874 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		903462 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		1309045 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56