HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: TP53B (Q12888)
TP53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Gene: TP53BP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.683

The method score is based on:

Property Details
Experiments 26831064, 29656893, 12364621, 17525332
Identification Methods affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002039 - p53 binding
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 5 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 1972
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024