HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	29180510, 37633270, 11927591, 19916563
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 129
+	Hs
		391581 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555327 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		555551 MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		1087090 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		391861 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		555617 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Hs
		1307111 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		H2A1J_HUMAN (1-127): 9.26e-66: 196: 96.06