HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	29180510, 27764250, 35271311
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 126
+	Hs
		749336 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707539 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		918565 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		1087364 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918638 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707725 BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		1307093 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		H2B1N_HUMAN (1-126): 3.35e-53: 164: 98.41