HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: SMC5 (Q8IY18)
Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)
Gene: SMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29656893, 36373674
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000724 - double-strand break repair via homologous recombination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006974 - DNA damage response and 1 others more... GO:0007059 - chromosome segregation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 1101
+	Hs
		749965 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		749801 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		SMC6_HUMAN (9-1069): 7.85e-63: 235: 15.55
+	Hs
		725099 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Hs
		1221609 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		SMC5_HUMAN (1-1101): 5.88e-124: 409: 100.00
+	Hs
		1266887 TOPB1_HUMAN (1122-1861): 3.79e-150: 505: 14.12		SMC4_HUMAN (2-1073): 2.02e-73: 268: 12.37
+	Hs
		1285830 TRI43_HUMAN (12-324): 9.24e-67: 235: 12.62		SMC3_HUMAN (51-1061): 6.65e-82: 293: 13.91
+	Hs
		522639 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH7_HUMAN (99-495): 1.01e-09: 65: 8.04
+	Hs
		528393 TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54		MYH6_HUMAN (108-441): 8.04e-09: 62.3: 9.74
+	Hs
		725238 TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30		MYH10_HUMAN (114-762): 2.31e-22: 106: 10.60
+	Mm
		1093546 TRI72_MOUSE (18-91): 9.41e-12: 71.5: 30.26		MYH9_MOUSE (651-991): 1.61e-13: 77.7: 11.21