HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.953

The method score is based on:

Property Details
Experiments 23157317, 33010150, 25184681, 29656893, 16391231, 23901102, 12697828, 11395493
Identification Methods affinity chromatography technology, proximity labelling technology, fluorescence microscopy
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains BRCT~BRCT, BRCT~PTCB-BRCT
Common GO terms GO:0000724 - double-strand break repair via homologous recombination
GO:0001673 - male germ cell nucleus
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 10 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1863
Hs

1 1522
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024