HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

The method score is based on:

Property	Details
Experiments	12700228, 11782371, 10655477, 9443979, 16860316, 16417649, 9926942
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002039 - p53 binding GO:0003684 - damaged DNA binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0016604 - nuclear body GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	1863
Hs

1	2442

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024