Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1
Interactor 2: CTIP (Q99708)
DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)
Gene: RBBP8
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 0.60 | 0.770 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25310973, 26387952, 10910365, 28132842, 31636387, 10764811, 20351172, 16843262, 11689934, 25184681, 25252691, 25659039, 14578343, 10196224, 9811458, 9738006, 27454289, 28398198, 29513652, 29656893 and 15 others
more... |
| Identification Methods | affinity chromatography technology, pull down, two hybrid, unspecified method, proximity labelling technology, enzymatic study, anti bait coimmunoprecipitation, isothermal titration calorimetry, tandem affinity purification, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000724 - double-strand break repair via homologous recombination GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair and 5 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
