HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: UB2J1 (Q9Y385)
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Gene: UBE2J1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1863 Hs			1 318
+	Hs
		749339 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		749252 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		749301 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		749256 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		749752 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2E3_HUMAN (2-156): 9.16e-63: 199: 26.58
+	Hs
		749782 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UB2E2_HUMAN (2-156): 2.19e-62: 198: 27.22
+	Hs
		919822 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849406 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895815 TRI68_HUMAN (12-388): 1.67e-74: 259: 11.31		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		895876 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		851867 TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		536779 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		537142 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2D4_HUMAN (10-156): 3.97e-70: 216: 28.00
+	Hs
		536760 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		536772 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		895851 TRI58_HUMAN (16-390): 3.39e-69: 243: 12.53		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		536763 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		536965 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2E3_HUMAN (2-156): 9.16e-63: 199: 26.58
+	Hs
		536996 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UB2E2_HUMAN (2-156): 2.19e-62: 198: 27.22
+	Hs
		536757 TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74		UBE2A_HUMAN (7-154): 3.69e-61: 193: 21.85