HitPredict

Interactor 1: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 19380743, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 679 Hs			1 304
+	Hs
		503632 HSP7C_HUMAN (51-653): 0: 883: 50.16		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		713922 HS71L_HUMAN (49-673): 0: 883: 47.59		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		564029 HSP76_HUMAN (49-673): 0: 875: 48.68		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		483780 HS71B_HUMAN (51-652): 0: 873: 49.27		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		503633 HSP7C_HUMAN (51-653): 0: 883: 50.16		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		503732 HSP7C_HUMAN (51-653): 0: 883: 50.16		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		503853 HSP7C_HUMAN (51-653): 0: 883: 50.16		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		713938 HS71L_HUMAN (49-673): 0: 883: 47.59		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		751568 GRP75_HUMAN (1-679): 0: 873: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		505017 HSP7C_HUMAN (51-653): 0: 883: 50.16		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		504539 HSP7C_HUMAN (51-653): 0: 883: 50.16		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		751750 GRP75_HUMAN (1-679): 0: 873: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Ce
		450542 HSP1_CAEEL (54-653): 0: 870: 50.81		Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22
+	Hs
		501799 BIP_HUMAN (53-677): 0: 566: 50.55		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		501953 BIP_HUMAN (53-677): 0: 566: 50.55		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		647814 HSP7C_CAEEL (53-677): 0: 567: 49.45		Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22
+	Hs
		501645 BIP_HUMAN (53-677): 0: 566: 50.55		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		502411 BIP_HUMAN (53-677): 0: 566: 50.55		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22