HitPredict

Interactor 1: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26291670
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 679 Hs			1 603
+	Hs
		504896 HSP7C_HUMAN (51-653): 0: 883: 50.16		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66
+	Hs
		564201 HSP76_HUMAN (49-673): 0: 875: 48.68		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66
+	Hs
		751869 GRP75_HUMAN (1-679): 0: 873: 100.00		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66
+	Hs
		504119 HSP7C_HUMAN (51-653): 0: 883: 50.16		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Sc
		478019 HSP77_YEAST (37-653): 0: 785: 66.61		CDC5_YEAST (30-571): 1.47e-144: 436: 29.05
+	Hs
		564080 HSP76_HUMAN (49-673): 0: 875: 48.68		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		503719 HSP7C_HUMAN (51-653): 0: 883: 50.16		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Hs
		564041 HSP76_HUMAN (49-673): 0: 875: 48.68		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Hs
		751545 GRP75_HUMAN (1-679): 0: 873: 100.00		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Dm
		332652 HSP7D_DROME (51-653): 0: 866: 50.97		PLK4_DROME (58-304): 7.62e-56: 203: 41.04
+	Hs
		160349 HSP7C_HUMAN (51-653): 0: 883: 50.16		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17
+	Hs
		160419 GRP75_HUMAN (1-679): 0: 873: 100.00		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17
+	Hs
		160460 HSP72_HUMAN (50-653): 0: 868: 49.11		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17
+	Hs
		502638 BIP_HUMAN (53-677): 0: 566: 50.55		KS6B2_HUMAN (53-412): 9.32e-134: 401: 24.66
+	Sc
		419770 HSP77_YEAST (37-653): 0: 785: 66.61		SNF1_YEAST (59-336): 1.66e-45: 172: 35.84
+	Sc
		419892 HSP7E_YEAST (29-653): 0: 766: 63.43		SNF1_YEAST (59-336): 1.66e-45: 172: 35.84
+	Hs
		502133 BIP_HUMAN (53-677): 0: 566: 50.55		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		501852 BIP_HUMAN (53-677): 0: 566: 50.55		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Hs
		160348 BIP_HUMAN (53-677): 0: 566: 50.55		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17