HitPredict

Interactor 1: GRP75 (P38646)
Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Heat shock protein family A member 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)
Gene: HSPA9

Interactor 2: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 679 Hs			1 518
+	Hs
		505013 HSP7C_HUMAN (51-653): 0: 883: 50.16		RIPK3_HUMAN (1-518): 1.15e-157: 460: 100.00
+	Hs
		714103 HS71L_HUMAN (49-673): 0: 883: 47.59		RIPK3_HUMAN (1-518): 1.15e-157: 460: 100.00
+	Hs
		504758 HSP7C_HUMAN (51-653): 0: 883: 50.16		Q9H4D1_HUMAN (20-286): 3.61e-38: 150: 35.74
+	Hs
		503777 HSP7C_HUMAN (51-653): 0: 883: 50.16		RIPK4_HUMAN (20-374): 1.35e-36: 146: 30.39
+	Hs
		502720 BIP_HUMAN (53-677): 0: 566: 50.55		RIPK3_HUMAN (1-518): 1.15e-157: 460: 100.00
+	Hs
		564185 HSP76_HUMAN (49-673): 0: 875: 48.68		Q9H4D1_HUMAN (20-286): 3.61e-38: 150: 35.74
+	Hs
		564048 HSP76_HUMAN (49-673): 0: 875: 48.68		RIPK4_HUMAN (20-374): 1.35e-36: 146: 30.39
+	Hs
		504035 HSP7C_HUMAN (51-653): 0: 883: 50.16		RIPK1_HUMAN (21-288): 1.18e-33: 137: 33.90
+	Hs
		713961 HS71L_HUMAN (49-673): 0: 883: 47.59		RIPK1_HUMAN (21-288): 1.18e-33: 137: 33.90
+	Hs
		201749 HSP7C_HUMAN (51-653): 0: 883: 50.16		RIPK2_HUMAN (14-291): 6.42e-33: 133: 32.32
+	Hs
		201765 HS71L_HUMAN (49-673): 0: 883: 47.59		RIPK2_HUMAN (14-291): 6.42e-33: 133: 32.32
+	Hs
		714021 HS71L_HUMAN (49-673): 0: 883: 47.59		ANKK1_HUMAN (14-294): 1.95e-32: 133: 30.41
+	Hs
		751616 GRP75_HUMAN (1-679): 0: 873: 100.00		RIPK1_HUMAN (21-288): 1.18e-33: 137: 33.90
+	Hs
		201751 HSP76_HUMAN (49-673): 0: 875: 48.68		RIPK2_HUMAN (14-291): 6.42e-33: 133: 32.32
+	Hs
		201771 HSP72_HUMAN (50-653): 0: 868: 49.11		RIPK2_HUMAN (14-291): 6.42e-33: 133: 32.32
+	Hs
		502560 BIP_HUMAN (53-677): 0: 566: 50.55		Q9H4D1_HUMAN (20-286): 3.61e-38: 150: 35.74
+	Hs
		501888 BIP_HUMAN (53-677): 0: 566: 50.55		RIPK4_HUMAN (20-374): 1.35e-36: 146: 30.39
+	Hs
		502070 BIP_HUMAN (53-677): 0: 566: 50.55		RIPK1_HUMAN (21-288): 1.18e-33: 137: 33.90