HitPredict

Interactor 1: NPL4 (P33755)
Nuclear protein localization protein 4 (HMG-CoA reductase degradation protein 4)
Gene: NPL4

Interactor 2: UBX2 (Q04228)
UBX domain-containing protein 2 (Secretion lowering protein 1)
Gene: UBX2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 0.55 0.699

The method score is based on:

Property Details
Experiments 16919153, 21211725, 16179952, 37968396, 38401542, 16429126
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000837 - Doa10p ubiquitin ligase complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0036503 - ERAD pathway
GO:0043130 - ubiquitin binding
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
and 1 others

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Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 11Aug2025