HitPredict

Interactor 1: SET1 (P38827)
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC 2.1.1.354) (COMPASS component SET1) (Lysine N-methyltransferase 2) (SET domain-containing protein 1)
Gene: SET1

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	18083099, 23453808, 30325428, 19398585, 17088385, 22158900, 11742990
Identification Methods	enzymatic study, methyltransferase assay
Interaction Type	direct interaction, methylation reaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1080 Sc			1 136
+	Sp
		457194 SET1_SCHPO (200-1080): 0: 565: 26.67		H31_SCHPO (1-136): 1.17e-59: 182: 92.65
+	Dm
		356118 ASH1_DROME (276-1079): 2.59e-103: 360: 15.50		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Hs
		935276 ASH1L_HUMAN (415-1079): 9.6e-97: 340: 16.33		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952649 ASH1L_HUMAN (415-1079): 9.6e-97: 340: 16.33		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Dm
		356084 SET1_DROME (399-1080): 3.85e-87: 311: 21.57		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Mm
		952747 EZH2_MOUSE (529-1064): 1.08e-90: 309: 17.91		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Hs
		934804 EZH2_HUMAN (529-1064): 7.13e-89: 304: 18.09		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952363 EZH2_HUMAN (529-1064): 7.13e-89: 304: 18.09		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		1079993 EZH2_HUMAN (529-1064): 7.13e-89: 304: 18.09		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Mm
		952754 Q6AXH7_MOUSE (529-1064): 5.02e-88: 301: 17.75		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Hs
		1080038 EZH2_HUMAN (529-1064): 7.13e-89: 304: 18.09		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	At
		886462 SUVH4_ARATH (495-1079): 2.43e-84: 288: 13.20		H33_ARATH (1-136): 4.81e-62: 187: 87.50
+	Hs
		935204 SETD2_HUMAN (513-1079): 2e-77: 282: 14.98		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		203659 SUV91_HUMAN (711-1079): 2.16e-84: 281: 18.99		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		1086306 SETD2_HUMAN (513-1079): 2e-77: 282: 14.98		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		203664 SUV91_HUMAN (711-1079): 2.16e-84: 281: 18.99		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		203722 SUV91_HUMAN (711-1079): 2.16e-84: 281: 18.99		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Hs
		203706 SUV91_HUMAN (711-1079): 2.16e-84: 281: 18.99		H37_HUMAN (1-136): 6.09e-59: 180: 86.77
+	Hs
		203711 SUV91_HUMAN (711-1079): 2.16e-84: 281: 18.99		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	Dm
		356072 EZ_DROME (503-1056): 5.38e-78: 274: 16.87		H3_DROME (1-136): 6.6e-61: 185: 88.97