HitPredict

Interactor 1: MPC2 (P38857)
Mitochondrial pyruvate carrier 2 (MPC2)
Gene: MPC2

Interactor 2: MPC3 (P53311)
Mitochondrial pyruvate carrier 3 (MPC3) (Protein FMP43)
Gene: MPC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	22628558
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0006850 - mitochondrial pyruvate transmembrane transport GO:0050833 - pyruvate transmembrane transporter activity GO:0098800 - inner mitochondrial membrane protein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 129 Sc			1 146
+	Sc
		859714 MPC1_YEAST (1-124): 7e-58: 177: 22.31		MPC3_YEAST (1-146): 8.59e-79: 231: 100.00
+	Sc
		861385 MPC3_YEAST (1-118): 1.37e-57: 176: 77.97		MPC3_YEAST (1-146): 8.59e-79: 231: 100.00
+	Sc
		756320 MPC2_YEAST (1-129): 1.6e-64: 193: 100.00		MPC2_YEAST (1-117): 3.55e-58: 178: 78.63
+	Sc
		756323 MPC2_YEAST (1-129): 1.6e-64: 193: 100.00		MPC1_YEAST (1-109): 1.33e-48: 154: 22.61
+	Sc
		859713 MPC1_YEAST (1-124): 7e-58: 177: 22.31		MPC1_YEAST (1-109): 1.33e-48: 154: 22.61
+	Hs
		316405 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC2_HUMAN (6-100): 3.82e-44: 142: 49.47
+	Hs
		316458 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC1_HUMAN (22-106): 3.67e-40: 132: 27.06
+	Hs
		316411 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC1L_HUMAN (22-95): 5.35e-32: 112: 28.38