HitPredict

Interactor 1: RPN10 (P38886)
26S proteasome regulatory subunit RPN10
Gene: RPN10

Interactor 2: PRS4 (P40327)
26S proteasome regulatory subunit 4 homolog (Tat-binding homolog 5)
Gene: RPT2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.718

Property	Details
Experiments	11805826, 16554755, 16429126, 17499717, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 268 Sc			1 437
+	Zm
		30770 A0A1D6KBS7_MAIZE (1-267): 2.53e-114: 334: 40.67		A0A1D6P390_MAIZE (59-431): 1.54e-160: 460: 42.63
+	Hs
		874063 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		PRS4_HUMAN (1-437): 6.83e-132: 388: 70.68
+	Hs
		906854 Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15		PRS4_HUMAN (1-437): 6.83e-132: 388: 70.68
+	At
		874025 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		PRS4A_ARATH (1-437): 7.3e-132: 388: 68.85
+	Hs
		56606 PIPSL_HUMAN (3-236): 1.17e-110: 340: 44.87		PRS4_HUMAN (1-437): 6.83e-132: 388: 70.68
+	Hs
		874066 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		PRS10_HUMAN (52-435): 5.01e-129: 379: 40.37
+	Dm
		820472 PSMD4_DROME (1-256): 5.75e-113: 332: 41.80		PRS4_DROME (1-437): 1.01e-133: 393: 70.84
+	Xl
		804063 Q4V845_XENLA (1-236): 2.49e-117: 342: 48.73		PRS8_XENLA (53-432): 4.06e-129: 382: 42.63
+	Hs
		874064 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		PRS8_HUMAN (38-432): 7.08e-126: 372: 42.42
+	Hs
		907062 Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15		PRS8_HUMAN (38-432): 7.08e-126: 372: 42.42
+	Hs
		798622 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		PRS6B_HUMAN (47-431): 1.61e-123: 366: 49.09
+	Hs
		798692 Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15		PRS6B_HUMAN (47-431): 1.61e-123: 366: 49.09
+	Dm
		874034 PSMD4_DROME (1-256): 5.75e-113: 332: 41.80		Q8SZ19_DROME (51-435): 6.17e-127: 374: 40.52
+	Sp
		293403 RPN10_SCHPO (1-261): 5.8e-112: 323: 45.59		PRS4_SCHPO (1-429): 3.73e-124: 369: 70.68
+	Sc
		703797 RPN10_YEAST (1-268): 3.42e-114: 330: 100.00		PRS6B_YEAST (57-419): 9.33e-112: 337: 48.77
+	Sc
		757011 RPN10_YEAST (1-268): 3.42e-114: 330: 100.00		PRS8_YEAST (106-429): 1.25e-104: 318: 49.38
+	Ce
		247733 PSMD4_CAEEL (1-240): 3.05e-92: 277: 39.26		PRS6B_CAEEL (57-430): 1.01e-123: 367: 51.07