HitPredict

Interactor 1: RPN10 (P38886)
26S proteasome regulatory subunit RPN10
Gene: RPN10

Interactor 2: DSK2 (P48510)
Ubiquitin domain-containing protein DSK2
Gene: DSK2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	17082762, 18995839, 33617881, 20064467, 26450923, 27698474, 20059542
Identification Methods	pull down, two hybrid, affinity chromatography technology, far western blotting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	VWA_2~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 268 Sc			1 373
+	At
		874016 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		RD23D_ARATH (3-370): 2.96e-75: 239: 18.90
+	At
		874019 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		RD23B_ARATH (3-372): 3.12e-69: 223: 15.94
+	At
		874018 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		RD23A_ARATH (3-369): 2.49e-66: 215: 16.41
+	Zm
		22892 A0A1D6KBS7_MAIZE (1-267): 2.53e-114: 334: 40.67		A0A1D6I428_MAIZE (3-370): 5.51e-67: 220: 12.14
+	At
		874017 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		RD23C_ARATH (3-370): 3.76e-61: 203: 15.77
+	Hs
		872125 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		RD23A_HUMAN (1-370): 2.33e-57: 192: 16.92
+	Rn
		1117345 Q9ESH1_RAT (1-236): 4.25e-119: 347: 49.15		RD23B_RAT (3-369): 2.17e-52: 181: 14.38
+	Hs
		872242 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		RD23B_HUMAN (3-369): 2.45e-50: 175: 13.70
+	Dm
		874035 PSMD4_DROME (1-256): 5.75e-113: 332: 41.80		Q9V3W9_DROME (3-370): 3.84e-54: 185: 14.88
+	Xl
		1118798 Q4V845_XENLA (1-236): 2.49e-117: 342: 48.73		BAG6A_XENLA (3-313): 1.38e-42: 160: 19.08
+	Hs
		803454 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		BAG6_HUMAN (2-313): 7.67e-32: 129: 20.74
+	Hs
		874069 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		RL40_HUMAN (3-73): 2.22e-28: 109: 36.11
+	Hs
		874198 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		UBQL1_HUMAN (73-370): 3.03e-20: 94.2: 17.61
+	Hs
		874195 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		UBQL2_HUMAN (73-370): 4.05e-19: 90.7: 20.25
+	Hs
		874104 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		NEDD8_HUMAN (5-71): 1.4e-21: 89.7: 39.71
+	Hs
		874185 PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15		UBQL4_HUMAN (74-370): 4.18e-18: 87.6: 13.64
+	Xl
		1118797 Q4V845_XENLA (1-236): 2.49e-117: 342: 48.73		Q9PVN8_XENLA (70-370): 9.6e-19: 89.6: 15.96
+	Dm
		874046 PSMD4_DROME (1-256): 5.75e-113: 332: 41.80		Q9VWD9_DROME (79-367): 2.13e-21: 97.7: 18.86
+	Dm
		874041 PSMD4_DROME (1-256): 5.75e-113: 332: 41.80		NEDD8_DROME (5-71): 2.03e-22: 92: 39.71
+	At
		874024 PSMD4_ARATH (1-243): 8.44e-117: 341: 45.71		DSK2B_ARATH (84-370): 1.69e-15: 79.5: 16.03