Interactor 1: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Interactor 2: RENT1 (Q92900)
Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)
Gene: UPF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.958

The method score is based on:

Property Details
Experiments 35271311, 19417104, 21145460, 20371770, 18066079, 18423202, 16452507
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Helicase_C~ResIII
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 6 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 411
Hs

1 1129
+ Hs
+ Hs
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+ Hs
+ Sc
+ Sc
+ Sc
+ Sc
+ Hs

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Last updated: 15 Jul 2024