HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	26186194, 28514442, 33961781, 23602568, 32296183, 23443559, unassigned1304, 24218572
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, lexa b52 complementation, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0010389 - regulation of G2/M transition of mitotic cell cycle and 1 others more... GO:0030332 - cyclin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 305
+	Hs
		625186 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		414796 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Mm
		763415 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK2_MOUSE (1-292): 1.46e-139: 399: 65.88
+	Hs
		758190 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Mm
		509470 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK1_MOUSE (1-290): 1.15e-136: 390: 66.32
+	Hs
		804104 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Xl
		1153623 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q6IRQ7_XENLA (1-294): 8.92e-148: 418: 75.51
+	Xl
		616668 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK2_XENLA (1-294): 1.88e-147: 417: 75.85
+	Hs
		625207 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Rn
		139842 O08769_RAT (7-156): 2.11e-38: 131: 25.83		CDK2_RAT (1-292): 4.66e-149: 421: 77.06
+	Hs
		625237 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Xl
		724512 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK1A_XENLA (1-300): 2.04e-138: 394: 64.78
+	Hs
		414811 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Mm
		803840 CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27		CDK2_MOUSE (1-292): 1.46e-139: 399: 65.88
+	Hs
		804106 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		414825 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		804108 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK17_HUMAN (1-291): 6.26e-124: 365: 53.43
+	Hs
		804083 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		836895 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		804107 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK16_HUMAN (1-288): 4.21e-108: 324: 54.33