HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	23602568, 23455922, 30833792, 33961781, 15890360, 23443559
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 292
+	Hs
		625186 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		758188 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Hs
		414796 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Mm
		763415 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Mm
		509470 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CDK1_MOUSE (1-289): 2.16e-133: 381: 56.70
+	Xl
		1153623 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q6IRQ7_XENLA (1-292): 8.06e-143: 405: 59.39
+	Xl
		616668 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK2_XENLA (1-292): 1.16e-142: 404: 59.73
+	Hs
		625207 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Hs
		804104 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK3_HUMAN (1-291): 4.77e-141: 401: 61.30
+	Rn
		139842 O08769_RAT (7-156): 2.11e-38: 131: 25.83		CDK2_RAT (1-292): 5.01e-144: 408: 60.07
+	Hs
		804106 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK5_HUMAN (1-292): 6.09e-139: 395: 100.00
+	Hs
		758199 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK18_HUMAN (1-286): 1.22e-108: 325: 56.94
+	Xl
		724512 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CDK1A_XENLA (1-289): 5.63e-134: 383: 56.01
+	Hs
		414811 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Mm
		803840 CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Hs
		300629 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CDK14_HUMAN (4-291): 1.17e-103: 311: 54.61
+	Hs
		804083 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24
+	Hs
		804108 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK17_HUMAN (1-291): 3.52e-121: 358: 55.82
+	Hs
		804107 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK16_HUMAN (1-286): 1.11e-115: 343: 57.99
+	Hs
		300630 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CDK14_HUMAN (4-291): 1.17e-103: 311: 54.61