HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

The method score is based on:

Property	Details
Experiments	14761977, 14633995, 20086099, 20308078, 17373842
Identification Methods	affinity chromatography technology, pull down, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest and 7 others more... GO:0009410 - response to xenobiotic stimulus GO:0009636 - response to toxic substance GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process GO:0051726 - regulation of cell cycle GO:0071480 - cellular response to gamma radiation
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	164
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024