HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: RBL2 (Q08999)
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Gene: RBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 23443559
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression GO:2000134 - negative regulation of G1/S transition of mitotic cell cycle
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 1139
+	Hs
		660099 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		RBL1_HUMAN (51-1139): 0: 1396: 50.59
+	Hs
		414198 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		RB_HUMAN (775-999): 1.19e-64: 239: 29.39
+	Hs
		414215 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		RB_HUMAN (775-999): 1.19e-64: 239: 29.39