HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	18263614, 15509808, 15286281
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007507 - heart development GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 2414
+	Hs
		804115 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		836901 CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		758299 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25