HitPredict

Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: Q8WUE3 (Q8WUE3)
CCNE2 protein (Cyclin E2)
Gene: CCNE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 374
+	Hs
		331630 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNE2_HUMAN (1-370): 8.1e-112: 334: 99.19
+	Hs
		624557 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNE1_HUMAN (1-368): 7e-110: 329: 49.87
+	Hs
		538489 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNB1_HUMAN (2-367): 1.56e-100: 306: 20.91
+	Hs
		303835 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNB2_HUMAN (1-362): 1.06e-100: 305: 21.45
+	Mm
		624384 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CCNB1_MOUSE (5-362): 5.3e-98: 299: 21.53
+	Hs
		758186 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNA1_HUMAN (106-367): 3.43e-91: 283: 25.56
+	Hs
		590139 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNA2_HUMAN (2-366): 2.38e-87: 272: 18.73
+	Hs
		87258 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		C9J2U0_HUMAN (16-368): 9.31e-87: 268: 42.98
+	Hs
		331632 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CCNE2_HUMAN (1-370): 8.1e-112: 334: 99.19
+	Mm
		763418 CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83		CCNA1_MOUSE (106-366): 5.33e-88: 273: 25.65
+	Xl
		841954 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CCNE1_XENLA (1-367): 1.09e-106: 320: 46.49
+	Xl
		193814 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		CCNE3_XENLA (1-367): 2.25e-105: 317: 45.68
+	Hs
		610199 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCNO_HUMAN (14-301): 5.05e-79: 248: 22.22
+	Hs
		538492 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CCNB1_HUMAN (2-367): 1.56e-100: 306: 20.91
+	Hs
		303836 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CCNB2_HUMAN (1-362): 1.06e-100: 305: 21.45
+	Hs
		673127 CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00		CCND3_HUMAN (98-329): 2.5e-70: 223: 25.31
+	Xl
		1146034 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q66J45_XENLA (13-369): 4.89e-88: 273: 22.19
+	Xl
		1151481 Q91646_XENLA (14-161): 6.75e-45: 148: 25.47		Q6GME9_XENLA (44-369): 5.3e-87: 270: 23.05
+	Hs
		590142 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CCNA2_HUMAN (2-366): 2.38e-87: 272: 18.73
+	Hs
		610200 CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46		CCNO_HUMAN (14-301): 5.05e-79: 248: 22.22