Interactor 1: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.806

The method score is based on:

Property Details
Experiments 12820963, 17325029
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Pkinase
Common GO terms GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0032991 - protein-containing complex
GO:0034198 - cellular response to amino acid starvation
GO:0045860 - positive regulation of protein kinase activity
and 1 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 164
Hs

1 1374
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024