HitPredict

Interactor 1: END3 (P39013)
Actin cytoskeleton-regulatory complex protein END3 (Endocytosis protein 3)
Gene: END3

Interactor 2: LAS17 (Q12446)
Proline-rich protein LAS17
Gene: LAS17

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	11805826, 18467557, 37968396, 16429126
Identification Methods	tandem affinity purification, protein complementation assay, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm GO:0007015 - actin filament organization GO:0030479 - actin cortical patch GO:0043332 - mating projection tip
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 349 Sc			1 633
+	Rn
		94091 ITSN1_RAT (3-326): 1.82e-59: 209: 13.40		F1LSG0_RAT (3-154): 4.14e-46: 172: 28.95
+	Dm
		1361426 Q9VIF7_DROME (3-349): 4.24e-61: 213: 16.36		Q9VAT0_DROME (3-215): 8.21e-40: 154: 18.18
+	Dm
		112580 M9ND00_DROME (3-349): 2.41e-60: 211: 15.58		Q9VAT0_DROME (3-215): 8.21e-40: 154: 18.18
+	Sc
		692255 PAN1_YEAST (4-82): 2.84e-14: 76.1: 27.50		LAS17_YEAST (1-633): 8.22e-51: 188: 100.00
+	Rn
		1126747 Q5JC29_RAT (10-223): 1.33e-30: 124: 20.83		SYNJ1_RAT (131-630): 3.06e-28: 123: 13.09
+	Hs
		126965 ITSN2_HUMAN (3-349): 5.91e-15: 78.1: 12.53		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Hs
		126936 ITSN1_HUMAN (124-241): 2.14e-09: 61.1: 12.30		WASL_HUMAN (3-154): 1.13e-42: 163: 28.29
+	Hs
		790688 ITSN2_HUMAN (3-349): 5.91e-15: 78.1: 12.53		WASP_HUMAN (3-448): 2.5e-27: 117: 16.52
+	Hs
		790676 ITSN1_HUMAN (124-241): 2.14e-09: 61.1: 12.30		WASP_HUMAN (3-448): 2.5e-27: 117: 16.52
+	Hs
		203228 ITSN1_HUMAN (124-241): 2.14e-09: 61.1: 12.30		SYNJ1_HUMAN (89-538): 6.62e-22: 103: 12.06